CP-24879 hydrochloride
CAS No. 10141-51-2
CP-24879 hydrochloride ( CP24879 hydrochloride; CP 24879 hydrochloride; CP-24879 HCl )
Catalog No. M27865 CAS No. 10141-51-2
CP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 84 | Get Quote |
|
10MG | 133 | Get Quote |
|
25MG | 260 | Get Quote |
|
50MG | 447 | Get Quote |
|
100MG | 651 | Get Quote |
|
500MG | 1368 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCP-24879 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionCP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.
-
DescriptionCP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.(In Vitro):CP-24879 hydrochloride (0-10 μM, 16 h) blocked LPS-induced expression of inflammatory cytokines in a concentration-dependent manner and showed the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes. CP-24879 hydrochloride (0-10 μM, 4 days) inhibited Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and a decrease in Leukotriene C4 (LTC4) production, and did not inhibit either 5-lipoxygenase or LTC4 synthase activity.(In Vivo):In Chow-fed and EFAD Balb/C mice, CP-24879 hydrochloride (3 mg/kg, i.p.) inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).
-
SynonymsCP24879 hydrochloride; CP 24879 hydrochloride; CP-24879 HCl
-
PathwayOthers
-
TargetOther Targets
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number10141-51-2
-
Formula Weight215.7
-
Molecular FormulaC11H18ClNO
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCl.CC(C)CCOc1ccc(N)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Scherm, Arthur; Peteri, Dezsoe. Piperazine derivatives and their use. Fr. Demande (1981), FR 2463768 A1 19810227.
molnova catalog
related products
-
Carboxyatractyloside...
Carboxyatractyloside is a natural product. It acts as an inhibitor of ADP/ATP carrier inhibits mitochondrial ADP/ATP transport.
-
Monoethyl pimelate
Monoethyl pimelate is a PROTAC linker, which refers to the alkyl/ether composition.
-
Acyl Carrier Protein...
Acyl Carrier Protein (ACP) (65-74) is an active acyl carrier protein (ACP) fragment.Acyl Carrier Protein (ACP) is a component of plastid-located plant fatty acid synthetase. It binds acyl groups covalently via the prosthetic group, 4-phosphopantetheine, during the biosynthesis of fatty acids.