CP-24879 hydrochloride
CAS No. 10141-51-2
CP-24879 hydrochloride ( CP24879 hydrochloride; CP 24879 hydrochloride; CP-24879 HCl )
Catalog No. M27865 CAS No. 10141-51-2
CP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 84 | Get Quote |
|
10MG | 133 | Get Quote |
|
25MG | 260 | Get Quote |
|
50MG | 447 | Get Quote |
|
100MG | 651 | Get Quote |
|
500MG | 1368 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCP-24879 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.
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DescriptionCP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.(In Vitro):CP-24879 hydrochloride (0-10 μM, 16 h) blocked LPS-induced expression of inflammatory cytokines in a concentration-dependent manner and showed the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes. CP-24879 hydrochloride (0-10 μM, 4 days) inhibited Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and a decrease in Leukotriene C4 (LTC4) production, and did not inhibit either 5-lipoxygenase or LTC4 synthase activity.(In Vivo):In Chow-fed and EFAD Balb/C mice, CP-24879 hydrochloride (3 mg/kg, i.p.) inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).
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SynonymsCP24879 hydrochloride; CP 24879 hydrochloride; CP-24879 HCl
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number10141-51-2
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Formula Weight215.7
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Molecular FormulaC11H18ClNO
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.CC(C)CCOc1ccc(N)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Scherm, Arthur; Peteri, Dezsoe. Piperazine derivatives and their use. Fr. Demande (1981), FR 2463768 A1 19810227.
molnova catalog
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