CP-24879 hydrochloride

CAS No. 10141-51-2

CP-24879 hydrochloride ( CP24879 hydrochloride; CP 24879 hydrochloride; CP-24879 HCl )

Catalog No. M27865 CAS No. 10141-51-2

CP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 84 Get Quote
10MG 133 Get Quote
25MG 260 Get Quote
50MG 447 Get Quote
100MG 651 Get Quote
500MG 1368 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    CP-24879 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.
  • Description
    CP-24879 hydrochloride, a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.(In Vitro):CP-24879 hydrochloride (0-10 μM, 16 h) blocked LPS-induced expression of inflammatory cytokines in a concentration-dependent manner and showed the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes. CP-24879 hydrochloride (0-10 μM, 4 days) inhibited Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and a decrease in Leukotriene C4 (LTC4) production, and did not inhibit either 5-lipoxygenase or LTC4 synthase activity.(In Vivo):In Chow-fed and EFAD Balb/C mice, CP-24879 hydrochloride (3 mg/kg, i.p.) inhibited approximately 80% combined Δ6 + Δ5 desaturase activities, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice, and increased OA and LA, with a higher ratio of LA/AA in the livers of mice injected with CP-24879 versus saline (4.70 vs 2.00, Chow-fed mice; 2.46 vs 1.40, EFAD mice; respectively).
  • Synonyms
    CP24879 hydrochloride; CP 24879 hydrochloride; CP-24879 HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    10141-51-2
  • Formula Weight
    215.7
  • Molecular Formula
    C11H18ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CC(C)CCOc1ccc(N)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Scherm, Arthur; Peteri, Dezsoe. Piperazine derivatives and their use. Fr. Demande (1981), FR 2463768 A1 19810227.
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